Publication List


Cox KL, Meng F, Wilkins KE, Li F, Wang P, Booher NJ, Carpenter SCD, Chen LQ, Zheng H, Gao X, Zheng Y, Fei Z, Yu JZ, Isakeit T, Wheeler T, Frommer WB, He P, Bogdanove AJ, Shan L. (2017) TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton. Nat Commun. 2017 May 24;8:15588. doi: 10.1038/ncomms15588.

Latorraca NR, Fastman NM, Venkatakrishnan AJ, Frommer WB. (2017) Dror RO, Feng L. Mechanism of Substrate Translocation in an Alternating Access Transporter. Cell. 2017 Mar 23;169(1):96-107.e12. doi: 10.1016/j.cell.2017.03.010.

Sugiyama A, Saida Y, Yoshimizu M, Takanashi K, Sosso D, Frommer WB, Yazaki K. (2017) Molecular Characterization of LjSWEET3, a Sugar Transporter in Nodules of Lotus japonicus. Plant Cell Physiol. 2017 Feb 1;58(2):298-306. doi: 10.1093/pcp/pcw190.


Kryvoruchko IS, Sinharoy S, Torres-Jerez I, Sosso D, Pislariu CI, Guan D, Murray J, Benedito VA, Frommer WB, Udvardi MK. (2016) MtSweet11, a Nodule-Specific Sucrose Transporter of Medicago tuncatula. Plant Physiol. 2016 May;171(1):554-65. doi: 10.1104/pp.15.01910

De Michele R., McFarlane H.E., Parsons H.T., Meents M.J., Lao J., González Fernández-Niño S., Petzold C.J., Frommer W.B., Samuels A.L. & Heazlewood J.L. (2016) Free-flow electrophoresis of plasma membrane vesicles enhances the quality of the proteome from Arabidopsis seedlings. J. Proteome Res. 15, 900-13 (PMID: 26781341).

Kryvoruchko I., Sinharoy S., Torres-Jerez I., Sosso D., Pislariu C., Guan D., Murray J., Benedito V., Frommer W.B. & Udvardi M. (2016) MtSWEET11, a nodule-specific sucrose transporter of Medicago truncatula root nodules. Plant Physiol. 171, 554-565 (PMID: 27021190)

Hu Y.B., Sosso D., Qu X.Q., Chen L.Q., Ma L., Chermak D., Zhang D.C. & Frommer W.B. (2016) Phylogenetic evidence for a fusion of archaeal and bacterial SemiSWEETs to form eukaryotic SWEETs and identification of SWEET hexose transporters in the amphibian chytrid pathogen Batrachochytrium dendrobatidis. FASEB J. 2016 Jul 13. pii: fj.201600576R. [Epub ahead of print] (PMID: 27411857)

Ho C. & Frommer W. B. (2016). Design and functional analysis of fluorescent nitrate and peptide transporter activity sensors in yeast cultures. Bio-protocol 6(3): e1728.

Feng L. & Frommer W.B. (2016) Evolution of Transporters: The relationship of SWEETs, PQ-loop, and PnuC transporters. Trends Biochem. Sci. 41, 118-119 (PMID: 26749089).


White F.F. & Frommer W.B. (2015) Deciphering durable resistance one R gene at a time. Nature Genet. 47, 1376-77.                                         (PMID: 26620111)

Sosso D., Li Q.B., Luo D., Schläpfer J., Gendrot G., Suzuki M., Koch K.E., McCarty D.R., Ross-Ibarra J., Rogowsky P., Chourey P.S., Yang B. & Frommer W.B. (2015) Seed filling in domesticated maize depends on SWEET-mediated trans-epithelial hexose transport. Nature Genet. 47, 1489-93 (PMID: 26523777)

             Highlighted on DOE Office of Science homepage ( and F1000

Provart N., Alonso J., Assmann S., Bergmann D., Brady S., Brkljacic J., Browse J., Chapple C., Colot V., Cutler S., Dangl J., Ehrhardt D., Friesner J, Frommer W.B., Grotewold E., Meyerowitz E., Nemhauser J., Nordborg M., Pikaard C., Shanklin J., Somerville C.R., Somerville S., Stitt M., Torii K., Waese J., Wagner D. & McCourt P. (2015) 50 Years of Arabidopsis research: highlights and future directions. New Phytol. 83, 1046-58 (PMID: 26465351).

Tao Y., Li S., Xu Y., Lily S. Cheung L.S., Eom J.S., Chen L.Q., Frommer W.B. & Feng L. (2015) Structure of a eukaryotic seven transmembrane SWEET transporter in a homo-trimeric complex. Nature 527, 259-63 (PMID: 26479032).

             Highlighted by DOE Office of Science homepage (

Chen H.-Y., Huh J.H., Yu Y.C., Ha L.H., Chen L.C., Tholl D., Frommer W.B. & Guo W.J. (2015) The Arabidopsis vacuolar sugar transporter SWEET2 limits carbon sequestration from roots and restricts Pythium infection. Plant J. 83, 1046-58 (PMID: 26234706).                                                               
Kikuta S., Hou B.H., Sato R., Frommer W.B. & Kikawada T. (2015) FRET sensor-based quantification of intracellular trehalose in mammalian cells. Biosci. Biotech. Biochem. 27, 1-4. (PMID: 26214383)                                                                                                                                                          
Ast C., De Michele R., Kumke M.U. & Frommer W.B. (2015) Single-fluorophore membrane transport activity sensors with dual-emission read-out. eLife 4:e07113 (PMID: 26090909)

Frommer W.B & Feng L. (2015) Structure and function of SemiSWEET sugar transporters. Trends Biochem. Sci. 40, 480-6 (PMID: 26071195).

Eom J.S., Chen L.Q., Sosso D., Julius, B.T., Lin IW., Qu X.Q. Braun D.M. & Frommer W.B. (2015) SWEETs, transporters for intra- and intercellular sugar translocation. Curr. Opin. Plant Biol. 25, 53-62 (PMID: 25988582).

Zhou J., Peng Z, Long J., Sosso D., Liu B., Eom J.S., Huang S., Vera Cruz C., Frommer W.B., White F.F. & Yang B. (2015) Gene targeting by the TAL effector PthXo2 reveals cryptic resistance gene for bacterial blight of rice. Plant J. 82, 632-43 (PMID: 25824104).

Chen L.Q., Lin I W., Qu XQ, Sosso D., McFarlane H.E., Londoño A., Samuels A.L. & Frommer W.B. (2015) A cascade three sequentially expressed SWEET sucrose efflux transporters in maternal tissues of the seed coat necessary for embryo nutrition. Plant Cell 27, 607-19 (PMID: 25794936).

              Highlighted by F1000

Rosas-Santiago P., Lagunas-Gómez D., Barkla B.J., Vera-Estrella R., Jones A., Lalonde S., Frommer W.B., Sychrová H., Zimmermannova O. & Pantoja O. (2015) The rice cornichon (OsCNIH1) cargo receptor interacts with the sodium transporter OsHKT1;3 and targets it to the Golgi. J. Exp. Bot. 66, 2733-48 (PMID: 25750424).

Chen L.Q, Cheung L., Feng L., Tanner W. & Frommer W.B. (2015) Transport of sugars. Annu. Rev. Biochem. 84, 865-94 (PMID: 25747398).
Ast C., Frommer W.B. & De Michele R. (2015) Quantification of extracellular ammonium concentrations and transporter activity in yeast using AmTrac fluorescent sensors. BioProtocols 5, 1, e1372. (


Cohn M., Bart R., Shybut M., Dahlbeck D., Gomez M., Morbitzer R., Hou B.H., Frommer W.B., Lahaye T. & Staskawicz B. (2014) Xanthomonas axonopodis virulence is promoted by TAL effector-mediated induction of a SWEET sugar transporter in cassava. Mol. Plant Microbe Interact. 27, 1186-98. (PMID: 25083909).

Xu Y., Tao Y, Cheung L., Fan C., Chen LQ, Xu S., Perry K., Frommer W.B. & Feng L. (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515, 448-52. (PMID: 25186729).

             Highlighted by DOE, Office of Science homepage as a Science Headline and F1000.

Denninger P., Bleckmann A., Lausser A., Vogler F., Ott T., Ehrhardt D.W., Frommer W.B., Sprunck S., Dresselhaus T. & Grossmann G. (2014) Male-female communication triggers calcium signatures during fertilization in Arabidopsis. Nature Comm. 5, 4645. (PMID: 25145880).

             Highlighted by F1000

Jones A.M., Xuan Y, Xu M., Wang R.S., Ho C.H., Lalonde S., You C.H., Sardi M.I., Parsa S.A., Smith-Valle E., Pilot G., Pratelli R., Grossmann G., Acharya B.R., Hu H.C., Engineer C., Villiers F., Takeda K., Assmann S.M., Chen J., Kwak J.M., Schroeder J.I., Albert R., Rhee S.Y. & Frommer W.B. (2014) Border control - a membrane-linked interactome of Arabidopsis. Science 344, 711-16. (PMID: 24833385).

             Highlighted by NSF News “Communicating with the world across the boarder" released May 16, 2014; F1000

Jones A.M., Danielson J.Å.H., Manoj-Kumar S., Lanquar V., Grossmann G. & Frommer W.B. (2014) Abscisic acid dynamics in roots detected with genetically encoded FRET sensors. eLife 3:e01741. (PMID: 24737862).

             Highlighted by: Choi & Gilroy (2014) Plant biologists FRET over stress. eLife 2014;3:e02763. DOI: 10.7554/eLife.02763. DOI:10.7554/eLife.01741; Williams R. (2014) Stressing and FRETing. The Scientist 28, Modus Operandi.

Ho C.H & Frommer W.B. (2014) Fluorescent sensors for activity and regulation of the nitrate transceptor CHL1/NRT1.1 and oligopeptide transporters. eLife 3, e01917. (DOI: 10.7554/eLife.01917; PMID: 24623305).

            Highlighted by NSF News ‘Nitrogen-tracking tools for better crops and less pollution’,  released Feb. 18, 2014

Lin I W., Sosso D., Chen L.Q., Gase K., Kim S.G., Kessler D., Klinkenberg P., Qu X.Q., Hou B.H., Carter C., Baldwin I.T. & Frommer W.B. (2014) Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9. Nature 508, 546-9. (PMID: 24670640).

            Highlighted in F1000

Zambon A., Zoso A., Luni C., Frommer W.B. & Elvassore N. (2014) Determination of glucose metabolic fluxes in live myoblasts by microfluidic nanosensing and data analysis. Integr. Biol. 6, 277-88 (PMID: 24424957).

De Michele R. & Frommer W.B. (2014) Mitochondrial Biosensors. Int. J. Biochem. Cell Biol. 48C, 39-44. (PMID: 24397954).

Hu Y., Zhang J., Jia H.G., Sosso D., Li T., Frommer W.B., Yang B., White F.F., Wang N. & Jones J.B. (2014) Lateral Organ Boundaries 1 is a disease susceptibility gene for citrus bacterial canker disease. Proc. Natl. Acad. Sci. USA 111, E521-9 (DOI:10.1073/pnas.1313271111).

Guo W.J., Nagy R., Chen S.Y., Frommer W.B. & Martinoia E. (2014) SWEET17, a facilitative fructose transporter in the tonoplast of Arabidopsis roots. Plant Physiol. 164, 777-89 (PMID: 24381066).

Lanquar V., Grossmann G., Thomine S. & Frommer W.B. (2014) Dynamic imaging of cytosolic zinc in Arabidopsis roots combining FRET sensors and RootChip technology. New Phytol. 202, 198-208 (PMID: 24372442).

             Highlighted in F1000 and by Michael J. Haydon, Getting a sense for zinc in plants, New Phytol. 2014, 202, 1


Xuan Y.H., Hu, Y.B., Chen L.Q., Sosso D., Ducat, D.C., Hou B.H. & Frommer W.B. (2013) Functional role of oligomerization for bacterial and plant sugar transporters of the SWEET family. Proc. Natl. Acad Sci USA 110, E3685-94.

             Highlighted in F1000

De Michele R., Ast C., Loqué D., Ho C.H., Andrade S.L.A., Grossmann G., Gehne S., Kumke M.U. & Frommer W.B. (2013) Fluorescent sensors reporting the activity of ammonium transceptors in live cells. eLife 2, e00800. (Correction: Elife. 2015 Feb 18;4. doi: 10.7554/eLife.06986).

             Comment by Wang & Javitch (2013) eLife 2013;2:e01029. DOI: 10.7554/eLife.01029; Highlighted by NSF News,Highlighted in F1000; Correction: Elife. 2015 Feb 18;4. DOI: 10.7554/eLife.06986

Schroeder J.I., Delhaize M., Frommer W.B., Guerinot M.L., Harrison M., Herrera-Estrella L., Horie, T., Kochian L., Munns R., Nishizawa N., Tsay Y.F. & Sanders D. (2013) Using membrane transporters to improve crops for sustainable food production. Nature 497, 60-66.

             Highlighted in F1000

Jones A., Grossmann G., Danielson, J.A.H., Sosso D., Chen L. Q., Ho, C.H. & Frommer W.B. (2013) In vivo biochemistry: Applications for small molecule biosensors in plant biology. Curr. Opin. Plant Biol. 16, 389-95.

Yuan L., Gu R., Loqué D., Frommer W.B. & von Wirén N. (2013) Allosteric regulation of transport activity by heterotrimerization of Arabidopsis ammonium transporter complexes in vivo. The Plant Cell 25, 974-84.

Bermejo C., Haerizadeh F., Sadoine M., Chermak D. & Frommer W.B. (2013) Differential regulation of glucose transport activity in yeast by specific cAMP signatures. Biochem. J. 452, 489-97.

Melo C.V., Okumoto S., Gomes J.R., Baptista M.S., Bahr B.A., Frommer W.B. & Duarte C.B. (2013) Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons. Neuroscience 237, 66-86.

Danielson J.A.H. & Frommer W.B. (2013) Plant science. Jack of all trades, master of flowering. Science 339, 659-60.

San Marten A., Gutierrez R., Ceballo S., Ruminot I., Lerchundi R., Baeza-Lehnert F., Frommer W.B., & Barros F.L. (2013) A genetically-encoded FRET lactate biosensor shows that neurons are energized by lactate. PLoS One 8(2), e57712. DOI: 10.1371/journal.pone.0057712.

Sosso D., Chen L.Q. & Frommer W.B. (2013) The SWEET glucoside transporter family. In: Encyl. Biophysics, (Roberts G., Ed.), Springer. 5, 2556-2558.


Xue W., Ruprecht C., Street N., Hematy K., Chang C., Frommer W.B., Persson T. & Niittylä T. (2012) Paramutation-like Interaction of T-DNA loci in Arabidopsis. PLoS One 7(12), e51651. DOI:10.1371/journal.pone.0051651.

Grossmann G., Meier M., Cartwright H.N., Sosso D., Quake S.R., Ehrhardt D.W. & Frommer W.B. (2012) Time-lapse fluorescence imaging of Arabidopsis root growth with rapid manipulation of the root environment using the RootChip. J Vis Exp. 65, 4290. DOI: 10.3791/4290.

Chen J., Lalonde S., Obrdlik P., Noorani Vatani A., Parsa S.A., Vilarino C., Revuelta J.L., Frommer W.B. & Rhee S.Y. (2012) Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Front Plant Sci. 3:124.

Funck D., Clauß K., Frommer W.B. and Hellmann H.A. (2012) The Arabidopsis CstF64-like RSR1/ESP1 protein participates in glucose signaling and flowering time control. Front. Plant Sci. 3:80. DOI: 10.3389/fpls.2012.00080.

Brutnell T. & Frommer W.B. (2012) Critic at large: Food for Thought. The Scientist 6, 23-25.

Jones A.M., Ehrhardt D.W. & Frommer W.B. (2012) A never ending race for new and improved fluorescent proteins. BMC Biol. 10, 39.
De Michele R., Lalonde S., Frommer W.B. & Loqué D. (2012) Ammonium and urea transporter inventory of the Selaginella genome. Front. Plant Sci. 3, 62.

Wipf D., Loqué D., Lalonde S. & Frommer W.B. (2012) Amino acid transporter inventory of the Selaginella genome. Front. Plant Sci. 3, 36. DOI: 10.3389/fpls.2012.00036.

Pratelli R., Guerra D.D., Yu S., Wogulis M., Kraft E., Frommer W.B., Callis J. & Pilot G. (2012) The ubiquitin E3 ligase LOSS OF GDU 2 is required for GLUTAMINE DUMPER 1- induced amino secretion in Arabidopsis. Plant Physiol. 158, 1628-42.

Lalonde S. & Frommer W.B. (2012) SUT sucrose and MST monosaccharide transporter inventory of the Selaginella genome. Front. Plant Sci. 3, 24. DOI: 10.3389/fpls.2012.00024.

Ehrhardt D.W. & Frommer W.B. (2012) New technologies for 21st century plant science. Plant Cell 24, 374-94.

Okumoto S., Jones A. & Frommer W.B. (2012) Quantitative imaging with fluorescent biosensors. Ann. Rev. Plant Biol. 63, 663-706.

Chen L.Q., Qu X.Q., Hou B.H., Osorio S., Fernie A.R. & Frommer W.B. (2012) Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Science 335, 207-211.

             PERSPECTIVE: Braun D.M. (2012) SWEET! The Pathway Is Complete. Science: 335, 173-174 DOI: 10.1126/science.1216828

             Highlighted in F1000

Frommer W.B. (2012) Genetically encoded biosensors. In: Strasburger: Textbook for Botany. Spektrum, Heidelberg


For past publications please click below attachment.