Wang Lab


Zhiyong Wang

  Dr. Zhiyong Wang

  Staff Scientist
  Department of Plant Biology
  Carnegie Institution for Science
  260 Panama Street
  Stanford, CA 94305

  Phone: (650) 739-4205
  Fax: (650) 325-6857 




75. Wang, W., Bai, M.-Y., Wang, Z.-Y. (2014) The brassinosteroid signaling network – a paradigm of signal integration. Curr. Opin. Plant Biol. 21, 147–153.

74. Ni, W.M., Xu, S.L., Tepperman, J.M., Stanley, D.J., Maltby, D.A., Gross, J.D., Burlingame, A.L., Wang, Z.-Y. Quail, P.H. (2014) A mutually assured destruction mechanism attenuates light signaling in Arabidopsis. Science. 344, 1160–1164.

73. Oh, E., Zhu, J.Y., Bai, M.-Y., Arenhart, R.A., Sun, Y., Wang, Z.-Y. (2014) Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl. eLife.03031. doi: 10.7554.

72. Oh, E., Zhu, J., Ryu, H., Hwang, I., Wang, Z.-Y. (2014) TOPLESS mediates brassinosteroid-induced transcriptional repression through interaction with BZR1. Nature Communications 18;5:4140. doi: 10.1038/ncomms5140.

71. Deng, Z., Oses-Prieto, J.A., Kutschera, U., Tseng, T.-S., Hao, L., Burlingame, A.L., Wang, Z.-Y., Briggs, W.R. (2014) Blue light-induced proteomic changes in etiolated Arabidopsis seedlings. J. Proteome Res. 13, 2524–2533.

70. Wang, W., Wang, Z.-Y. (2014) At the intersection of plant growth and immunity. Cell Host Microbe 15, 400–402.

69. Fan, M., Bai, M.Y., Kim, J.G., Wang, T., Oh, E., Chen, L., Park, C.H., Son, S.H., Kim, S.K., Mudgett, M.B., Wang, Z.Y. (2014) The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis. Plant Cell. 26, 828–841.

68. Arenhart, R.A., Bai, Y., de Oliveira, L.F.V., Neto, L.B., Schunemann, M., Maraschin, F.S., Mariath, J., Silverio, A., Sachetto-Martins, G., Margis, R., Wang, Z.Y., Margis-Pinheiro, M. (2014) ASR5 is a major transcription regulator for aluminum responsive gene expression in rice. Mol. Plant. 7, 709–721.

67. Wang, W., Li, G., Zhao, J., Chu, H., Zhang, D., Wang, Z.Y., Liang, W. (2014) DWARF TILLER1, a WUSCHEL-Related Homeobox Transcription Factor, Is Required for Tiller Growth in Rice. PLoS Genet 10(3): e1004154.

66. Wang, C.-M., Shang, J.-X., Chen, Q.-X., Oses-Prieto, J.A., Bai, M.-Y., Yang, Y., Yuan, M., Zhang, Y.-L., Mu, C.-C., Deng, Z., Wei, C.-Q., Burlingame, A.L., Wang, Z.-Y., Sun, Y. (2014) Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification. Mol. Cell Proteomics. 12, 3653–3665.

65. Xu, P., Xu, S.-L., Li, Z.-J., Tang, W., Burlingame, A.L., Wang, Z.-Y. (2014) A Brassinosteroid-Signaling Kinase Interacts with Multiple Receptor-Like Kinases in Arabidopsis. Mol Plant. 7, 441–444.



64. Kim, M.H., Kim, Y., Kim, J.W., Lee, H.S., Lee, W.S., Kim, S.K., Wang, Z.Y., Kim, S.H. (2013) Identification of Arabidopsis BAK1-Associating Receptor-Like Kinase 1 (BARK1) and Characterization of its Gene Expression and Brassinosteroid-Regulated Root Phenotypes. Plant Cell Physiol. 54, 1620–1634.

63. Youn, J.H., Kim, T.W., Kim, E.J., Bu, S., Kim, S.K., Wang, Z.Y., Kim, T.W. (2013) Structural and functional characterization of Arabidopsis GSK3-like kinase AtSK12. Mol. Cell. 36, 564–570.

62. Ni, W., Xu, S.L., Chalkley, R.J., Pham, T.N., Guan, S., Maltby, D.A., Burlingame, A.L., Wang, Z.-Y., Quail, P.H. (2013) Multisite Light-Induced Phosphorylation of the Transcription Factor PIF3 Is Necessary for Both Its Rapid Degradation and Concomitant Negative Feedback Modulation of Photoreceptor phyB Levels in Arabidopsis. Plant Cell 25, 2679–2698.

61. Jiang, W.B., Huang, H.Y., Hu, Y.W., Zhu, S.W., Wang, Z.-Y., Lin, W.H. (2013) Brassinosteroid Regulates Seed Size and Shape in Arabidopsis. Plant Physiol. 162, 1965–1977.

60. Zhong, S.H., Liu, J.Z., Jin, H., Lin, L., Li, Q., Chen, Y., Yuan, Y.X., Wang, Z.-Y., Huang, H., Qi, Y.J., Chen, X.Y., Vaucheret, H., Chory, J., Li, J., He, Z.H. (2013) Warm temperatures induce transgenerational epigenetic release of RNA silencing by inhibiting siRNA biogenesis in Arabidopsis. Proc. Natl. Acad. Sci. USA. 110, 9171–9176.

59. Huang, H.Y., Jiang, W.B., Hu, Y.W., Wu, P., Zhu, J.Y., Liang, W.Q., Wang, Z.-Y., Lin, W.H. (2013) BR signal influences Arabidopsis ovule and seed number through regulating related genes expression by BZR1. Mol. Plant 6, 456–469.

58. Zhu, J.-Y., Sae-Seaw, J., Wang, Z.-Y. (2013) Brassinosteroid signalling. Development. 140, 1615–1620.



57. Wang, Z.-Y., Bai, M.Y., Oh, E., Zhu, J.Y. (2012) Brassinosteroid signaling network and regulation of photomorphogenesis. Annu. Rev. Genet. 46, 701–724.

56. Gendron, J.M., Liu, J.-S., Fan, M., Bai, M.-Y., Wenkel, S., Springer, P.S., Barton, M.K., Wang, Z.-Y. (2012) Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis. Proc Natl Acad Sci USA 109, 21152–21157.

55. Bai, M.-Y., Fan, M., Oh, E., Wang, Z.-Y. (2012) A triple-HLH/bHLH Cascade Controls Cell Elongation Downstream of Multiple Hormonal and Environmental Signaling Pathways in Arabidopsis. Plant Cell, 24, 4917–4929.

54. Wang, X., Zhang, J., Yuan, M., Ehrhardt, D. W., Wang, Z.-Y., Mao, T. (2012) Arabidopsis MICROTUBULE DESTABILIZING PROTEIN40 Is Involved in Brassinosteroid Regulation of Hypocotyl Elongation. Plant Cell. 24, 4012–4025.

53. Oh, E., Zhu, J.-Y., Wang, Z.-Y. (2012) Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses. Nature Cell Biol. 14, 802–809.

52. Bai, M.-Y., Shang, J.-X., He, J.-X., Oh, E., Fan, M., Bai, Y., Zentella, R., Sun, T-P., Wang, Z.-Y. (2012) Brassinosteroid, gibberellin, and phytochrome impinge on a common transcription module in Arabidopsis. Nature Cell Biol. 14, 810–819.

51. Wang, Z.-Y. (2012) Brassinosteroids modulate plant immunity at multiple levels. Proc. Natl. Acad. Sci. USA. 109, 7–8.

50. Kim, T.W., Michniewicz, M., Bergmann, D.C., Wang, Z.-Y. (2012) Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway. Nature 482, 419–422.

49. Fan, X.Y., Sun, Y., Cao, D.M., Bai, M.Y., Luo, X.M., Yang, H., Wei, C., Zhu, S., Sun, Y., Chong, K., Wang, Z.-Y. (2012) BZS1, a B-box Protein, Promotes Photomorphogenesis Downstream of Both Brassinosteroid and Light Signaling Pathways. Mol. Plant 5, 591–600.

48. Hao, Y., Oh, E., Choi, G., Liang, Z., Wang, Z.-Y. (2012) Interactions between HLH and bHLH Factors Modulate Light-Regulated Plant Development. Mol. Plant 5, 688–697.

47. Yan, L., Ma, Y., Liu, D., Wei, X., Sun, Y., Chen, X., Zhao, H., Zhou, J., Wang, Z.Y., Shui, W., Lou, Z. (2012) Structural basis for the impact of phosphorylation on plant receptor-like kinase BAK1 activation. Cell Research 22, 1304–1308.

46. Deng, Z., Xu, S., Chalkley, R.J., Oses-Prieto, J.A., Burlingame, A.L., Wang, Z.-Y., Kutschera, U. (2012) Rapid auxin-mediated changes in the proteome of the epidermal cells in rye coleoptiles: implications for the initiation of growth. Plant Biol. 14, 420–427.

45. Kutschera, U., Wang, Z.-Y. (2012) Brassinosteroid action in flowering plants: a Darwinian perspective. J. Exp. Bot. 63, 3511–3522.

44. Xu, S.L., Chalkley, R.J., Wang, Z.-Y., Burlingame, A.L. (2012) Identification of O-linked β-D: -N-acetylglucosamine-Modified Proteins from Arabidopsis. Methods Mol. Biol. 876, 33–45.

43. Deng, Z., Bu, S., Wang Z.-Y. (2012) Quantitative analysis of protein phosphorylation using two-dimensional difference gel electrophoresis. Methods Mol. Biol. 876, 47–66.

42. Zhu, J.-Y., Sun, Y., Wang, Z.-Y. (2012) Genome-wide identification of transcription factor binding sites in plants using chromatin immunoprecipitation followed by microarray (ChIP-chip) or Sequencing (ChIP-seq). Methods Mol. Biol. 876, 173–188.

41. Lu, S.X., Webb, C.J., Knowles, S.M., Kim, S.H.J., Wang, Z.-Y., Tobin, E.M. (2012) CCA1 and ELF3 Interact in the Control of Hypocotyl Length and Flowering Time in Arabidopsis. Plant Physiol. 158, 1079–1088.

40. Kim, T.-W., Guan, S., Burlingame, A.L., Wang, Z.-Y. (2011) The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2. Mol. Cell 43, 561–571.

39. She, J., Han, Z., Kim, T.W., Wang, J., Cheng, W., Chang, J., Shi, S., Yang, M., Wang, Z.-Y., Chai, J. (2011) Structural insight into brassinosteroid perception by BRI1. Nature 474, 472–476.

38. Tang, W., Yuan, M., Wang, R., Yang, Y., Wang, C., Oses-Prieto, J.A., Kim, T.-W., Zhou, H.-W., Deng, Z., Gampala, S.S., Gendron, J.M., Jonassen, E.M., Lillo, C., DeLong, A., Burlingame, A.L., Sun, Y., Wang, Z.-Y. (2011) PP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1. Nature Cell Biol. 13, 124–131.

37. Li, T., Xu, S.-L., Oses-Prieto, J.A., Putil, S., Xu, P., Wang, R.-J., Li, K.-H., Maltby, D.A., An, L.-Z., Burlingame, A.L., Wang, Z.-Y. (2011) Proteomics analysis reveals post-translational mechanisms for cold-induced metabolic changes in Arabidopsis. Mol. Plant 4, 361–374.

36. Samuel, M.A., Tang, W., Jamshed, M., Northey, J., Patel, D., Smith, D., Siu, K.W., Muench, D.G., Wang, Z.-Y., Goring, D.R. (2011) Proteomic analysis of Brassica stigmatic proteins following the self-incompatibility reaction reveals a role for microtubule dynamics during pollen responses. Mol. Cell Proteomics 10, M111 011338.

35. Kim, T.-W., Wang, Z.-Y. (2010) Brassinosteroid signal transduction from receptor kinases to transcription factors. Annu. Rev. Plant Biol. 61, 681–704.

34. Sun, Y., Fan, X.-Y., Cao, D.-M., He, K., Tang, W., Zhu, J.-Y., He, J.-X., Bai, M.-Y., Zhu, S.-W., Oh, E., Patil, S., Kim,T.-W., Ji, H., Wong, H., Rhee, S.Y., Wang, Z.-Y. (2010) Integration of brassinosteroid signal transduction with the transcription network for plant growth regulation in Arabidopsis. Dev. Cell 19, 756–777.

33. Luo, X.-M., Lin, W.-H., Zhu, S.-W., Zhu, J.-Y., Sun, Y., Fan, X.-Y., Cheng, M., Hao, Y., Oh, E., Tian, M., Liu, L., Zhang, M., Xie, Q., Chong, K., Wang, Z.-Y. (2010) Integration of light- and brassinosteroid-signaling pathways by a GATA transcription factor in Arabidopsis. Dev Cell. 19, 872–883.

32. Wang, Z.-Y., Choi, G. (2010) From Receptors to Responses. Curr. Opin. Plant Biol. 13, 485–488.

31. Tang, W., Deng, Z., Wang, Z.-Y. (2010) Proteomics shed light on the brassinosteroid signaling mechanisms. Curr. Opin. Plant Biol. 13, 27–33.

30. Wang, F., Bai, M.-Y., Deng, Z., Oses-Prieto, J.A., Burlingame, A.L., Lu, T., Chong, K., Wang, Z.-Y. (2010) Proteomic study identifies proteins involved in brassinosteroid regulation of rice growth. J. Integr. Plant Biol. 52, 1075–1085.

29. Kutschera, U., Deng, Z., Oses-Prieto, J.A., Burlingame, A.L., Wang, Z.-Y. (2010) Cessation of coleoptile elongation and loss of auxin sensitivity in developing rye seedlings. A quantitative proteomic analysis. Plant Signal. Behav. 5, 509–517.

28. Kim, T.-W., Guan, S., Sun, Y., Deng, Z., Shang, J.-X., Sun, Y., Burlingame, A.L., Wang, Z.-Y. (2009) Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nature Cell Biol. 11, 1254–1262.

27. Zhang, L.-Y., Bai, M.-Y., Wu, J., Zhu, J.-Y., Wang, H. ,Wang, W., Zhang, Z., Sun, Y. Zhao, J., Sun, X., Yang , H., Xu, Y., Kim, S.-W., Fujioka, S., Lin, W.-H., Chong ,K., Lu, T.-G., Wang, Z.-Y. (2009) Antagonistic HLH/bHLH transcription factors mediate BR regulation of cell elongation and plant development in rice and Arabidopsis. Plant Cell 21, 3767–3780.

26. Wang, L., Wang, Z., Xu, Y., Yoo, S.-H., Xue, Z., Xu, Z., Wang, Z.-Y., Chong, K. (2009) OsGSR1 is involved in crosstalk between gibberellins and brassinosteroids in rice. Plant J. 57, 498–510.

25. Peng, Z.Y., Zhou, X., Li, L., Yu, X., Li, H., Jiang, Z., Cao, G., Bai, M., Wang, X., Jiang, C., Lu, H., Hou, X., Qu, L., Wang, Z.-Y., Zuo, J., Fu, X., Su, Z., Li, S., Guo, H. (2009) Arabidopsis Hormone Database: a comprehensive genetic and phenotypic information database for plant hormone research in Arabidopsis. Nucleic Acids Res. 37 (Database issue), D975–982.

24. Tang, W., Kim, T.-W., Oses-Prieto, J.A., Sun, Y., Deng, Z., Zhu, S., Wang, R., Burlingame, A.L., Wang, Z.-Y. (2008) BSKs mediate signal transduction from the receptor kinase BRI1 in Arabidopsis. Science 321, 557–560.

23. Tang, W., Deng, Z., Oses-Prieto, J.A., Suzuki, N., Zhu, S., Zhang, X., Burlingame, A.L., Wang. Z.-Y. (2008) Proteomic studies of brassinosteroid signal transduction using prefractionation and 2-D DIGE. Mol. Cell Proteomics 7, 728–738.

22. Gendron, J.M., Haque, A., Gendron, N., Chang, T., Asami, T., Wang, Z.-Y. (2008) Chemical genetic dissection of brassinosteroid-ethylene interaction. Mol. Plant 1, 368–379.

21. Gu, Y., Deng, Z., Paredeza, A.R., DeBolt, S., Wang, Z.-Y., Somerville, C. (2008) Prefoldin 6 is required for normal microtubule dynamics and organization in Arabidopsis. Proc. Natl. Acad. Sci. USA 105, 18064–18069.

20. Gampala, S.S., Kim, T.-W., He, J.-X., Tang, W., Deng, Z., Bai, M.-Y., Guan, S., Lalonde, S., Sun,Y., Gendron, J.M., Chen, H., Shibagaki, N., Ferl, R.J., Ehrhardt, D., Chong, K., Burlingame, A.L., Wang, Z.-Y. (2007) An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev. Cell 13, 177–189.

19. Bai, M.-Y., Zhang, L.-Y., Gampala, S.S., Zhu, S.-W., Song, W.-Y., Chong, K., Wang, Z.-Y. (2007) Functions of OsBZR1 and 14-3-3 proteins in brassinosteroid signaling in rice. Proc. Natl. Acad. Sci. USA 104, 13939–13844.

18. Gendron, J.M., Wang, Z.-Y. (2007) Multiple mechanisms modulate brassinosteroid signaling. Curr. Opin. Plant Biol. 10, 436–441.

17. Deng, Z., Zhang, X., Tang, W., Oses-Prieto J.A., Suzuki, N., Gendron, J.A., Chen, H., Guan, S., Chalkley, R.J., Kaye Peterman, T., Burlingame, A.L., Wang, Z.-Y. (2007) A Proteomic Study of brassinosteroid response in Arabidopsis. Mol. Cell Proteomics 6, 2058–2071.

16. Zhang, X., Chen, Y., Wang, Z.Y., Chen, Z., Gu, H., Qu, L.J. (2007) Constitutive expression of CIR1 (RVE2) affects several circadian-regulated processes and seed germination in Arabidopsis. Plant J. 51, 512–525.


Before 2007:

15. Wang, Z.-Y., Wang, Q., Chong, K., Wang, F., Wang, L., Bai, M., Jia, C. (2006) The brassinosteroid signal transduction pathway. Cell Research. 16, 427–434.

14. Shi, Y.-H., Zhu, S.-W., Mao, X.-Z., Feng, J.-X., Zhang, L., Cheng, J., Wei, L.-P., Wang, Z.-Y., Zhu, Y.-X. (2006) Transcriptome Profiling, Molecular Biological and Physiological Studies Reveal a Major Role for Ethylene in Cotton Fiber Cell Elongation. Plant Cell 18, 651–664.

13. He, J.-X., Gendron, J.M., Sun, Y., Gampala, S.S.L., Gendron, N., Sun, C.Q., Wang, Z.-Y. (2005) BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses. Science 307, 1634–1638.

12. Wang, Z.-Y., He, J.-X. (2004) Brassinosteroid signal transduction: choices of signals and receptors. Trends Plant Sci. 9, 91–96.

11. Thain, S.C., Vandenbussche, F., Laarhoven, L.J., Dowson-Day, M.J., Wang, Z.-Y., Tobin, E.M., Harren, F.J., Millar, A.J., Van Der Straeten, D. (2004) Circadian rhythms of ethylene emission in Arabidopsis. Plant Physiol. 136, 3751–3761.

10. He, J.-X., Gendron, J.M., Yang, Y., Li, J., Wang, Z.-Y. (2002) The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1, a positive regulator of the brassinosteroid signaling pathway in Arabidopsis. Proc. Natl. Acad. Sci. USA 99, 10185–10990.

9. Wang, Z.-Y., Nakano, T., Gendron, J.M., He, J., Chen, M., Vafeados, D., Yang, Y., Fujioka, S., Yoshida, S., Asami, T., Chory, J. (2002) Nuclear-localized BZR1 mediates brassinosteroid-induced growth and feedback suppression of brassinosteroid biosynthesis. Dev. Cell 2, 505–513.

8. Yin, Y., Wang, Z.-Y., Mora-Garcia, S., Li, J., Yoshida, S., Asami, T., Chory, J. (2002) BES1 accumulates in the nucleus in response to brassinosteroids to regulate gene expression and promote stem elongation. Cell 109, 181–191.

7. Green, R.M., Tingay, S., Wang Z.-Y., Tobin, E.M. (2002) Circadian rhythms confer a higher level of fitness to Arabidopsis plants. Plant Physiol. 129, 576–584.

6. Wang, Z.-Y., Setu, H., Fujioka, S., Yoshida, S., Chory, J. (2001) BRI1 is a critical component of a plasma membrane receptor for plant steroids. Nature 410, 380–383.

5. He, Z., Wang, Z.-Y., Li, J., Zhu, Q., Lamb, C., Ronald, P., Chory, J. (2000) Perception of brassinosteroids by the extracellular domain of the receptor kinase BRI1. Science 288, 2360–2363.

4. Weigel, D., Ahn, J.H., Blazquez, M.A., Borevitz, J.O., Christensen, S.K., Fankhauser, C., Ferrandiz, C., Kardailsky, I., Malancharuvil, E.J., Neff, M.M., Nguyen, J.T., Sato, S., Wang, Z.-Y., Xia, Y., Dixon, R., Harrison, M.J., Lamb, C.J., Yanofsky, M.F., Chory, J. (2000) Activation tagging in Arabidopsis. Plant Physiol. 122, 1003–1013.

3. Sugano, S., Andronis, C., Green, R.M., Wang, Z.-Y., Tobin, E.M. (1998) Protein kinase CK2 interacts with and phosphorylates the Arabidopsis circadian clock-associated 1 protein. Proc. Natl. Acad. Sci. USA 95, 11020–11025.

2. Wang, Z.-Y., Tobin, E.M. (1998) Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression. Cell 93, 1207–1217.

1. Wang, Z.-Y., Kenigsbuch, D., Sun, L., Harel, E., Ong, M.S., Tobin, E.M. (1997) A Myb-related transcription factor is involved in the phytochrome regulation of an Arabidopsis Lhcb gene. Plant Cell 9, 491–507.